Heading into the weekend, Wolves hold a one-point and one-place advantage over the North London outfit, with the teams sitting in sixth and seventh position respectively.
While Wolves are unbeaten in the Premier League since September 22, Spurs have recorded nine points from four games since the arrival of Jose Mourinho.
Here, Sports Mole predicts how Spurs may line up for their visit to the West Midlands.
Having chosen to rest a number of players for the Champions League fixture with Bayern Munich in midweek, Mourinho could revert to the team which began the 5-0 win over Burnley last weekend.
Mourinho will hope to have more options at his disposal, with Harry Winks, Tanguy Ndombele and Erik Lamela having almost recovered from injury.
However, given the magnitude of the fixture, it appears unlikely that any of the trio will be included in the starting lineup.