The Belgian international suffered the problem during the club's 3-1 defeat to Sunderland in the Asia Cup.
Manager Andre Villas-Boas told reporters: "Jan has had damage to his ligaments, and he is most likely to be out of training for around two to three weeks."
Vertonghen made 48 appearances during his debut season at White Hart Lane.
Restore Data
| Team | P | W | D | L | F | A | GD | PTS | |
| 1 | Arsenal | 34 | 24 | 5 | 5 | 82 | 26 | 56 | 77 |
| 2 | Liverpool | 33 | 22 | 8 | 3 | 75 | 32 | 43 | 74 |
| 3 | Manchester CityMan City | 32 | 22 | 7 | 3 | 76 | 32 | 44 | 73 |
| 4 | Aston Villa | 34 | 20 | 6 | 8 | 71 | 50 | 21 | 66 |
| 5 | Tottenham HotspurSpurs | 32 | 18 | 6 | 8 | 65 | 49 | 16 | 60 |
| 6 | Newcastle UnitedNewcastle | 32 | 15 | 5 | 12 | 69 | 52 | 17 | 50 |
| 7 | Manchester UnitedMan Utd | 32 | 15 | 5 | 12 | 47 | 48 | -1 | 50 |
| 8 | West Ham UnitedWest Ham | 34 | 13 | 9 | 12 | 54 | 63 | -9 | 48 |
| 9 | Chelsea | 32 | 13 | 8 | 11 | 61 | 57 | 4 | 47 |
| 10 | Brighton & Hove AlbionBrighton | 32 | 11 | 11 | 10 | 52 | 50 | 2 | 44 |
| 11 | Wolverhampton WanderersWolves | 33 | 12 | 7 | 14 | 46 | 53 | -7 | 43 |
| 12 | Fulham | 34 | 12 | 6 | 16 | 50 | 54 | -4 | 42 |
| 13 | Bournemouth | 33 | 11 | 9 | 13 | 48 | 60 | -12 | 42 |
| 14 | Crystal Palace | 33 | 9 | 9 | 15 | 42 | 56 | -14 | 36 |
| 15 | Brentford | 34 | 9 | 8 | 17 | 52 | 59 | -7 | 35 |
| 16 | Everton | 33 | 10 | 8 | 15 | 34 | 48 | -14 | 30 |
| 17 | Nottingham ForestNott'm Forest | 34 | 7 | 9 | 18 | 42 | 60 | -18 | 26 |
| 18 | Luton TownLuton | 34 | 6 | 7 | 21 | 47 | 75 | -28 | 25 |
| 19 | Burnley | 34 | 5 | 8 | 21 | 37 | 69 | -32 | 23 |
| 20 | Sheffield UnitedSheff Utd | 33 | 3 | 7 | 23 | 31 | 88 | -57 | 16 |
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