The hosts have been on a poor run of form and are just two points above the dropzone, while Tottenham are three points off the top four.
Here, Sports Mole rounds up all of the latest team news for the two clubs.
Sports Mole's predicted XI: Darlow; Manquillo, Lascelles, Clark, Dummett; Willock, Shelvey, Hendrick; Joelinton, Almiron, Fraser
Sports Mole's predicted XI: Lloris; Tanganga, Sanchez, Rodon, Reguilon; Lo Celso, Ndombele, Hojbjerg, Lucas; Kane, Vinicius
Watch the Sports Mole Football Shorts prediction for this game below: