Alderweireld played the full 90 minutes of Tottenham's 2-0 win over Newport County in the FA Cup on Wednesday night.
The Belgium international has not featured in the Premier League since the end of October, however, due to a long-term hamstring problem.
The 28-year-old has been tipped to resume his partnership with Jan Vertonghen this weekend, although Pochettino refused to give anything away when questioned on the matter during his pre-match press conference.
"No decision. Yesterday was a game that was important to win and I am happy because the team showed a solid, professional performance and I am happy with everyone," Pochettino told reporters.
Tottenham will enter this weekend's match one place and four points above sixth-placed Arsenal in the Premier League table.