Spurs may have lost 2-1 to Arsenal in the Premier League on Sunday, but they are strong favourites to overcome the Croatian champions, who are without a manager after Zoran Mamic took the decision to resign after being given a prison sentence.
Here, Sports Mole rounds up all of the latest team news for the two clubs.
Out: Sadegh Moharrami (muscle)
Sports Mole's predicted XI: Livakovic; Ristovski, Lauritsen, Theophile-Catherine, Gvardiol; Majer, Jakic, Ademi, Ivanusec, Orsic; Petkovic
Sports Mole's predicted XI: Lloris; Doherty, Sanchez, Dier, Davies; Sissoko, Winks; Lamela, Alli, Bergwijn; Vinicius