Spurs boss Andre Villas-Boas, who won the European trophy with Porto before beginning his nine-month stint at Chelsea last season, is likely to make changes to his side that defeated Reading 3-1 on Sunday.
The North London club's in-form striker Jermain Defoe could be dropped for tomorrow night's clash, which could make way for Emmanuel Adebayor, who signed a permanent contract with Spurs in the summer.
Meanwhile, Vladamir Petkovic, who has witnessed his side win their last five games, is expected to opt for Miroslav Klose as the side's main attacking threat, with Stefano Mauri providing support to the German.
Tottenham: Lloris; Walker, Gallas, Vertonghen, Naughton; Dembele, Sandro; Lennon, Dempsey, Bale; Adebayor
Lazio: Marchet; Scaloni, Biava, Dias, Cavanda; Ledesma; Ederson, Cana, Hernanes, Mauri; Klose
Sports Mole says: 1-1