The Premier League has today revealed the fixture list for the 2022-23 campaign, which for Southampton begins with a trip to Tottenham Hotspur.
Southampton's first home match of the campaign will come a week later against Leeds United, before a difficult end to the month sees them face Leicester City, Manchester United and Chelsea.
October will be particularly busy for Ralph Hasenhuttl's side, as the campaign will be halted in November and December due to the 2022 World Cup.
As it stands, the Saints are set to end their season at home to Liverpool on May 28.
Southampton's 2022-23 Premier League fixtures in full:
August
6 - Tottenham (A)
13 - Leeds United (H)
20 - Leicester City (A)
27 - Manchester United (H)
31 - Chelsea (H)
September
3 - Wolverhampton Wanderers (A)
10 - Brentford (H)
17 - Aston Villa (A)
October
1 - Everton (H)
8 - Manchester City (A)
15 - West Ham United (H)
18 - AFC Bournemouth (A)
22 - Arsenal (H)
29 - Crystal Palace (A)
November
5 - Newcastle United (H)
12 - Liverpool (A)
December
26 - Brighton & Hove Albion (H)
31 - Fulham (A)
January
2 - Nottingham Forest (H)
14 - Everton (A)
21 - Aston Villa (H)
February
11 - Wolverhampton Wanderers (H)
18 - Chelsea (A)
25 - Leeds United (A)
March
4 - Leicester City (H)
11 - Manchester United (A)
18 - Tottenham Hotspur (H)
April
1 - West Ham United (A)
8 - Manchester City (H)
15 - Crystal Palace (H)
22 - Arsenal (A)
26 - AFC Bournemouth (H)
29 - Newcastle United (A)
May
6 - Nottingham Forest (A)
13 - Fulham (H)
20 - Brighton & Hove Albion (A)
28 - Liverpool (H)
