He will be complemented by Paraguay's key man Miguel Almiron as part of a front two, built on solid foundations at the back.
Almiron has made himself a crucial cog for Newcastle United with consistent performances behind the front line, hugely boosting their attack with impressive build-up play.
At the other end of the pitch, West Ham United centre-back Fabian Balbuena should come into the side at the heart of the defence, despite featuring sporadically for the Hammers in the Premier League this season.
They will shield experienced goalkeeper Antony Silva, who plies his trade in Mexico for Puebla.
Paraguay possible starting lineup: Silva; Rojas, Gomez, Balbuena, Alonso, Arzamendia; Villasanti, Gimenez, Cardozo Lucena; Romero, Almiron