The deadline-day signing made his debut in the Champions League win at Paris St Germain but did not make the squad against Chelsea or RB Leipzig after contracting coronavirus.
Arsenal will welcome back a host of regular names who were rested for the Europa League win over Dundalk on Thursday.
Mikel Arteta is without a number of defenders with David Luiz (thigh), Rob Holding (hamstring), Pablo Mari (ankle) and Calum Chambers (knee) all missing through injury, although William Saliba is available to make his debut if called upon.
Manchester United provisional squad: De Gea, Henderson, Grant, Wan-Bissaka, Fosu-Mensah, Maguire, Tuanzebe, Lindelof, Shaw, Williams, Pogba, McTominay, Fernandes, Fred, Matic, Van De Beek, James, Pellistri, Mata, Greenwood, Rashford, Cavani, Ighalo.
Arsenal provisional squad: Leno, Runarsson, Bellerin, Maitland-Niles, Gabriel, Mustafi, Saliba, Kolasinac, Tierney, Saka, Ceballos, Elneny, Partey, Willock, Xhaka, Nelson, Pepe, Smith Rowe, Willian, Aubameyang, Lacazette, Nketiah.