The Red Devils could secure a top-four finish, and delay Manchester City's coronation, with a victory, whereas Liverpool find themselves playing catch-up in the race for Champions League football next season.
Here, Sports Mole looks at the team news for both sides ahead of the mouth-watering showdown.
Sports Mole's predicted XI: Henderson; Wan-Bissaka, Lindelof, Maguire, Shaw; Fred, McTominay; Rashford, Fernandes, Pogba; Cavani
Sports Mole's predicted XI: Alisson; Alexander-Arnold, Fabinho, Kabak, Robertson; Thiago, Wijnaldum; Salah, Firmino, Mane; Jota
Watch the Sports Mole Football Shorts prediction for this game below: