With Sunderland leading 1-0 in the first half, United's Spanish goalkeeper threw himself to his right to turn Emanuele Giaccherini's header around the post.
After the match manager David Moyes conceded that De Gea had kept his side in the contest, while former United keeper Peter Schmeichel described the stop as one of the best that he has ever seen in the Premier League.
But where do De Gea's heroics rank among other saves? Here, Sports Mole has picked out 10 more that we believe run it close.
Tomasz Kuszczak - Wigan Athletic vs. West Bromwich Albion, 2006
Peter Schmeichel - Liverpool vs. Manchester United, 1993
Edwin van der Sar - Fulham vs. Man United, 2010
Carlo Cudicini - Tottenham Hotspur vs. Chelsea, 2008
Peter Schmeichel - Everton vs. Man United, 1997
Tomasz Kuszczak - Birmingham City vs. Manchester United, 2007
Craig Gordon - Sunderland vs. Bolton Wanderers, 2010
David de Gea - Chelsea vs. Man United, 2012
David James - Chelsea vs. Manchester City, 2005
Peter Schmeichel - Newcastle United vs. Man United, 1997