The 29-year-old has been named in attacking midfield for the Red Devils, four days after arriving from Arsenal in a high-profile swap deal.
Also included is club captain Michael Carrick, who has been absent since September with an irregular heart rhythm.
Spanish midfielder Juan Mata is the only player to retain his spot in the starting lineup, featuring alongside Sanchez and Scott McTominay in a four-man attack line that is likely to be spearheaded by Marcus Rashford.
In terms of the League Two hosts, boss Darren Way has made two changes to the team that lost to Chesterfield last time out.
Yeovil Town: Krysiak; James, Sowunmi, N Smith, Dickson; Bird, Gray, Green, Wing; Zoko, Surridge
Subs: Maddison, Whelan, C.Smith, Gobern, Santos, Browne, Fisher
Manchester United: Romero; Darmian, Lindelof, Rojo, Shaw; Carrick, Herrera; Mata, McTominay, Sanchez; Rashford
Subs: Pereira, Smalling, Young, Gomes, Lingard, Matic, Lukaku
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