The Spain international has been left out for the Citizens' wins over Chelsea and Arsenal in the Community Shield and league respectively over the past fortnight, but returns for today's first home outing of the campaign to reach the landmark milestone.
Former City player Aaron Mooy misses out as his partner is due to give birth, while Jonathan Hogg and Mathias Jorgensen also make way in place of Tommy Smith, Jon Gorenc Stankovic and Abdelhamid Sabiri.
City have failed to score in four successive home league matches against the Terriers, most recently playing out a 0-0 draw in May.
Manchester City: Ederson; Laporte, Stones, Kompany, Mendy; Fernandinho; Gundogan, David Silva, Bernardo Silva; Gabriel Jesus, Aguero
Subs: Bravo, Walker, Sterling, Sane, Mahrez, Otamendi, Foden
Huddersfield Town: Hamer; Kongolo, Smith, Schindler, Hadergjonaj; Sabiri, Stankovic, Billing; Pritchard, Lowe; Mounie
Subs: Lossl, Williams, Mbenza, van La Parra, Sobhi, Diakhaby, Depoitre
Follow all of the action as it unfolds with Sports Mole's live text coverage right here.