Head coach Pep Guardiola recently reiterated the importance of rotating his squad, and there will be a number of changes from the side that started Tuesday's 2-1 win over Borussia Dortmund in the Champions League.
Bernardo Silva could move back to a midfield position, with Guardiola likely to have one eye on next week's Champions League clash with Dortmund and the upcoming FA Cup semi-final with Chelsea.
Gabriel Jesus was on the scoresheet in Man City's 2-0 win over Leicester City in the Premier League last weekend, and the Brazilian could again operate out wide with Aguero going through the middle.
Man City possible starting lineup: Ederson; Walker, Dias, Laporte, Mendy; B Silva, Fernandinho, Gundogan; Sterling, Aguero, Jesus
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