While City can win the top-flight crown with victory in the North East, defeat for Manchester United against Leicester City or Liverpool will see Pep Guardiola and his squad celebrate before facing the Magpies.
However, the Spaniard will want to see a much-improved performance after City lost out to fellow Champions League finalists Chelsea at the Etihad Stadium on Saturday.
Here, Sports Mole rounds up all of Man City's latest injury and suspension news ahead of their 36th league fixture of the season.
Type of injury: Muscle
Possible return date: Unknown
Guardiola opted to protect De Bruyne at the weekend with the playmaker said to be suffering from muscle fatigue. While the Belgian is said to be recovering from the issue, Friday's game comes too soon for his return.
MAN CITY'S SUSPENSION LIST
With John Stones having served his three-match ban, City have no suspension issues ahead of this contest.