The home side beat Elche last weekend to move into seventh spot in the table, while Betis currently occupy 10th, having picked up 16 points from their opening 13 matches of the season.
Granada's involvement in the Europa League means that it has been a busy start to the season for the club, but they will be relatively pleased with their league form this term and managed to book their spot in the knockout round of the European competition, with a two-legged affair against Napoli to come in February.
Diego Martinez's side also ensured that they would progress to the second round of the Copa del Rey courtesy of a 2-0 victory away to San Juan on Thursday night.
A record of five wins, three draws and four defeats in La Liga this season has seen Granada collect 18 points from 12 matches, which has left them in seventh spot in the table ahead of the next set of fixtures.
El Grana, who finished seventh in La Liga last term, beat Elche 1-0 last weekend courtesy of a strike from Luis Suarez as they won in the league for the first time since the end of October.
Manuel Pellegrini's side have picked up four points from their last two league matches, meanwhile, including a welcome point against high-flying Villarreal last weekend.
Betis have largely struggled for consistency this term, though, winning five, drawing one and losing seven of their 13 matches to collect 16 points, which has left them in 10th position.
Los Verdiblancos, who finished 15th in La Liga last term, are actually without a victory in their last four league games with Granada and suffered a 1-0 defeat in the corresponding game in 2019-20.
Granada La Liga form: DLLLDW
Granada form (all competitions): LLDDWW
Real Betis La Liga form: WLLLWD
Real Betis form (all competitions): LLLWDW
There are not expected to be any surprises further forward, though, with Luis Milla, Yangel Herrera and Maxime Gonalons likely to play behind a front three of Suarez, Darwin Machis and Roberto Soldado.
Head coach Pellegrini is unlikely to make any changes from the side that started against Villarreal last weekend, with Aitor Ruibal expected to retain his spot in a wide area.
Cristian Tello, Antonio Sanabria and Joaquin appeared off the bench against the Yellow Submarine and are options for change in the final third, but Borja Iglesias should again lead the Betis line this weekend.
Granada possible starting lineup:
Silva; Foulquier, Duarte, Sanchez, Neva; Herrera, Milla, Gonalons; Machis, Soldado, Suarez
Real Betis possible starting lineup:
Bravo; Emerson, Mandi, Bartra, Moreno; Carvalho, Guardado, Rodriguez; Ruibal, Iglesias, Fekir
We say: Granada 1-1 Real Betis
There is not too much between these two teams in terms of quality, and it would not be a surprise to see a close game despite the fact that Granada have performed slightly better this season. Betis will certainly have taken confidence from their last three results and should have enough to claim a point here.