The away side have lost each of their last three games and still have work to do if they are to cement their place in contention for European football next season.
Emmen were beaten for the first time since February as Ajax claimed a 4-0 win on Sunday, which confirmed their status as champions.
Notwithstanding, they are just a point away from safety which makes for good reading given that they were rock-bottom at some point.
Sunday's hosts must now put that loss behind them and focus on their remaining three fixtures beginning with the visit of this weekend's opponents.
The most recent meeting between the sides was a 1-1 draw in March's reverse fixture at the Hitachi Capital Mobility Stadion.
Groningen's bad run of form continues as they were defeated for the fourth time in five outings on Sunday when they lost 2-1 at home to Sparta Rotterdam.
Danny Buijs's men are still on course to secure a European place, but they no longer have margin for error with Sparta bearing down on them.
With a clash against AZ Alkmaar set to follow, the importance of a win this weekend for the visitors cannot be overstated if they are to ward off the challenge of fellow European hopefuls.
Luciano Carty is a major doubt for the home side with a shoulder problem which has kept him out of action for the past five months.
Nick Bakker is expected to be sidelined for a third game running as the Dutch defender continues to struggle with a knock.
Keziah Veendorp has been the biggest beneficiary of Bakker's absence, and he is in line for a third consecutive start.
Arjen Robben was given a 30-minute cameo appearance last time out as Danny Buijs continues to slowly ease the veteran winger back into action.
The visiting side will have to make do with the unavailability of Gabriel Gudmundsson, who was forced off 27 minutes into Groningen's last away outing.
Emmen possible starting lineup:
Verrips; Cavlan, Veendorp, Araujo, Bijl; Moussa, Vlak, Pena; Frei, Adzic, De Leeuw
Groningen possible starting lineup:
Padt; Van Hintum, Itakura, Te Wierik, Dankerlui; Schreck, Van Kaam; Suslov, El Hankouri, Da Cruz; Strand Larsen
We say: Emmen 2-1 Groningen
With their survival hopes still hanging in the balance, the onus to claim all three points is more on the home team this weekend. We expect them to rise to the occasion, and get one over the visitors come the full-time whistle.