When asked about the possibility of those two signing on for MLS clubs, Vermes identified Toronto FC and Los Angeles Galaxy as potential destinations.
"Defoe I think is a done deal already, that's just my opinion - to Toronto," he told Sky Sports News. "Frank was linked last year and I think he stayed on because Mourinho went back. There is a good chance that he will make the move to LA Galaxy."
Vermes recently guided his side to the MLS Cup at the expense of Real Salt Lake.