However, Bournemouth have lost six of their last seven games and manager Eddie Howe will be keen to end that run ahead of a tough run of fixtures during the Christmas period.
Chelsea have been far from convincing since returning to action after the November international break, but Maurizio Sarri's side remain in the top four of the Premier League table and have qualified for the last 32 of the Europa League.
The Italian can also guide his team to a place in the last four of the EFL Cup with victory on Wednesday night, but the recently-appointed boss will acknowledge that the Blues are still falling short of the standards expected of them.
There is an argument that Chelsea have not delivered a convincing performance in a meaningful game since the 4-0 demolition of Burnley on October 28, but that may change as Sarri tinkers with his team over a hectic period.
The former Napoli chief has handed starts to just 17 different players in the Premier League this season, and squad members will be keen to use games such as the one this week to stake their claim for an outing in the top flight.
Emerson Palmieri will hope that a strong showing in this game can lead to more outings over the coming weeks, but it remains to be seen whether Ethan Ampadu and Callum Hudson-Odoi will be given an appearance in this fixture.
The pair both featured in Chelsea's final two group games in the Europa League, but Sarri has held each youngster back for the ties with Liverpool and Derby County earlier in this competition.
However, that approach suggests that Sarri has ambitions to win this trophy, and with a team full of players keen to make an impression, it is difficult to back against the West Londoners reaching the semi-finals.
Recent form: WW
Recent form (all competitions): WWLWDW
Bournemouth have been flying high in the top half of the Premier League table for the opening four months of the campaign, but a disappointing run of results have left Howe's men in 11th place.
The Cherries boss has remained positive in the media when asked about his side's form, but there will be concern that an excellent start to the season will be undone by the turn of the year.
Bournemouth are still just three points off sixth-placed Manchester United, although trips to Tottenham Hotspur and United are still to come during the final weeks of 2018.
That double-header places more emphasis on registering a positive result against Chelsea, and getting back to winning ways is as much of a priority as reaching the last four of a cup competition.
Bournemouth had performed relatively well in the EFL Cup since their promotion to the Premier League three-and-a-half years ago, but they are yet to make that step past the last eight and emerging victorious on Wednesday evening would break new ground.
The draw has been kind to the south coast outfit, with home victories coming against lower-league opposition in each of their previous three ties, although late goals were required to get past Blackburn Rovers and Norwich City respectively.
Injuries will prevent Howe from being able to rotate his squad like in previous rounds, however, and that could prove to be a blessing in disguise as he looks for a response to Saturday's 2-0 defeat at Wolverhampton Wanderers.
Howe will still have one eye on an important home showdown with Brighton & Hove Albion at the weekend, but expect a strong showing from the visitors as they look to avoid extending their dismal run.
Recent form: WW
Recent form (all competitions): LLLWLL
Sarri may decide against taking any kind of a risk with Eden Hazard, who sustained a minor knock during Sunday's victory at Brighton.
Victor Moses and Morata are also huge fitness doubts, but Sarri will still be able to make widespread alterations ahead of Saturday's Premier League fixture with Leicester City.
Gary Cahill could return after a recent injury to take his place in a much-changed back four, while Cesc Fabregas could feature in the centre of a midfield three which also includes Loftus-Cheek and Barkley.
Howe must also decide whether to risk Callum Wilson from the start after the forward's return from a minor injury at the weekend.
Chelsea possible starting lineup:
Caballero; Zappacosta, Christensen, Cahill, Palmieri; Loftus-Cheek, Fabregas, Barkley; Willian, Giroud, Pedro
Bournemouth possible starting lineup:
Boruc; Simpson, S.Cook, Ake, Rico; Brooks, Surman, Lerma, Pugh; King; Mousset
Head To Head
Wednesday's fixture represents just the 14th competitive contest between the two clubs, with Chelsea registering 10 wins in comparison to three victories for Bournemouth.
Eight of those matches have taken place since December 2015, and Bournemouth have twice recorded a victory at Stamford Bridge during that period.
However, Chelsea prevailed by a 2-1 scoreline when the two teams met at this stage of the competition almost a year to the day of this week's encounter.
We say: Chelsea 3-1 Bournemouth
Chelsea are likely to make more alterations than Bournemouth for this contest, but we still expect a Blues win. Many of Sarri's squad are match-fit due to the Europa League and they should be sharp enough to get the better of the Cherries.