Since being battered 4-0 by Bayern Munich exactly a month ago, the German side have won four and drawn one game in all competitions.
Visiting Chelsea are definitely without left-back Ashley Cole, whose place in defence should be taken by Ryan Bertrand.
In attack, Fernando Torres is likely to lead the line after Samuel Eto'o started Saturday's Premier League win over Cardiff, with Oscar also set to be named in Jose Mourinho's lineup after scoring as a substitute at Stamford Bridge.
When these two sides last met in the group stage in 2007, it finished 0-0 at the Veltins-Arena.
Possible starting lineups
Schalke: Hildebrand; Uchida, Santana, Howedes, Aogo; Neustadter, Boateng; Clemens, Meyer, Draxler; Szalai
Chelsea: Cech; Ivanovic, Cahill, Terry, Bertrand; Ramires, Obi Mikel; Mata, Oscar, Hazard; Torres
Sports Mole says: 1-1