The Blucerchiati have lost three games on the spin but are already assured of a place in the top flight for another season, unlike already-relegated opponents Brescia.
Claudio Ranieri took over as Sampdoria head coach in October with the club bottom of Serie A after suffering six defeats in their first seven matches.
Fast forward nine months and the Italian, now best known for winning the Premier League title with Leicester City in 2016, has pulled off what he set out to achieve.
Indeed, Ranieri got Sampdoria over the line with time to spare thanks to a run of five wins in six matches between July 1 and July 19.
La Samp have since lost to Genoa, Juventus and AC Milan, but they can be forgiven for losing a little focus after confirming survival a couple of weeks ago.
Wednesday's 4-1 loss to Milan was disappointing, with Zlatan Ibrahimovic stealing the show courtesy of two goals and an assist at the Marassi.
Sampdoria can now finish no higher than 14th and no lower than 16th, but Ranieri will be eager to end the season with three more points this weekend.
That does not seem like the toughest of tasks, either, given that opponents Brescia are 19th in the table, having collected just 24 points from a possible 111.
Only basement side SPAL have been in worse form than Brescia over the past month - and the whole season, of course - though they have a chance to bow out on a relative high.
Revenge will also be on the agenda for the hosts, having lost the reverse fixture 5-1 in January - Fabio Quagliarella helping himself to a couple of goals in that one.
Lecce are the only side to have shipped more goals than Brescia this term, and coming off the back of defeats to Lecce, Parma and Lazio, it is tough to see them stopping the rot.
Brescia's Serie A form: LLWLLL
Sampdoria's Serie A form: WWWLLL
Brescia possible starting lineup:
Andreanacci; Semprini, Mateju, Gastaldello, Mangraviti; Zmrhal, Tonali, Dessena, Spalek; Torregrossa, Aye
Sampdoria possible starting lineup:
Falcone; Tonelli, Yoshida, Chabot, Augello; Depaoli, Thorsby, Linetty, Jankto; Gabbiadini, Quagliarella
We say: Brescia 0-2 Sampdoria
Sampdoria have followed up three wins in a row with three successive defeats. Ranieri can be pleased with his work this season, however, having inherited a side bottom of the table, and he will be confident of ending the campaign with three more points.