On the back of three successive defeats, the Terriers travel to the West Midlands knowing that a further setback will leave them facing an uphill battle to avoid dropping into League One.
When Danny Cowley was appointed as Huddersfield boss during the early weeks of the season, the Terriers hierarchy would have been demanding stability over looking to earn an immediate return to the Premier League.
However, the Yorkshire outfit are now under real threat of suffering back-to-back relegations after losing three games in a row without scoring a goal from open play.
Although Huddersfield are still within three points of 18th-placed Charlton Athletic, Cowley will acknowledge that his players are running out of time to turn things around.
From a certain standpoint, a visit to Birmingham is the perfect fixture at this time, and it begins a run of five games against opposition who are either out of form or no higher than mid-table.
Nevertheless, while those games offer a window of opportunity for Huddersfield, the longer it takes to get another win on the board will only increase the stakes heading into their next outing.
With Pep Clotet having already revealed that he will be leaving at the end of the season, Birmingham will be content with simply avoiding becoming embroiled in any kind of a relegation battle.
However, while five points from six games have kept Blues out of trouble for now, defeat on Wednesday would leave the club just four points above their next opponents.
Such a scenario highlights that they can ill-afford to take their foot off the gas at this stage, something which would have undoubtedly been told to the players after their showing against Hull City last weekend.
While the West Midlands outfit fought back from 2-0 down to claim a 3-3 draw, it represented a missed opportunity to put 11 points between them and the bottom three.
Birmingham City Championship form: DDDLDD
Huddersfield Town Championship form: LWWLLL
Having contributed two assists after coming off the substitutes' bench on Saturday, Jeremie Bela will expect to be handed a recall to the Birmingham starting lineup.
Huddersfield will be without midfielder Juninho Bacuna after his red card against Nottingham Forest on Sunday.
Cowley is unlikely to be shy when it comes to making alterations to his team with changes expected in all areas of the pitch.
Birmingham City possible starting lineup:
Camp; Colin, Dean, Clarke-Salter, Pedersen; Crowley, Gardner, Bellingham, Bela; Hogan, Jutkiewicz
Huddersfield Town possible starting lineup:
Lossl; Duhaney, Schindler, Stankovic, Toffolo; Chalobah, Hogg; Rowe, O'Brien, Pritchard; Grant
We say: Birmingham City 2-1 Huddersfield Town
At some stage, Huddersfield are likely to get back on track. However, despite the quality and experience which Cowley has at his disposal, we feel that a hard-working performance from the home side will get the job done on Wednesday night.