The injury-plagued Gerard Pique forced his way into Koeman's back three for their 4-0 Copa del Rey final win over Athletic Bilbao, but Ronald Araujo may be given the nod alongside Clement Lenglet and Oscar Mingueza if no risks are taken over Pique's fitness.
Sergi Roberto is also pushing for inclusion over Sergino Dest, but the former Ajax man should continue on the right-hand side for this game, while Jordi Alba is assured of a place on the left after claiming two assists in the Copa del Rey final.
Ousmane Dembele is pining for a start amid speculation surrounding contract talks, but Koeman should keep his faith in Antoine Griezmann up top for this midweek encounter, while Ansu Fati and Philippe Coutinho are long-term absentees and Martin Braithwaite has sprained an ankle.
Lionel Messi will hope to avoid a fourth consecutive home game without a goal against Getafe, but his 23 strikes in the 2020-21 La Liga campaign is more than the entire Azulones team (22).
Barcelona possible starting lineup:
Ter Stegen; Araujo, Lenglet, Mingueza; Dest, De Jong, Busquets, Pedri, Alba; Messi, Griezmann