The Gunners enter the weekend's action 10th in the table, while United are at the foot of the division with just 14 points from a possible 90.
Sports Mole rounds up all of the latest team news for the two clubs.
Out: Sander Berge (thigh), Billy Sharp (muscle), Chris Basham (unspecified), Jack Robinson (unspecified), Jack O'Connell (knee), Jack Rodwell (unspecified)
Doubtful: George Baldock (concussion), Jayden Bogle (concussion)
Sports Mole's predicted XI: Ramsdale; Egan, Ampadu, Jagielka; Stevens, Lundstram, Norwood, Fleck, Osborn; McGoldrick, McBurnie
Sports Mole's predicted XI: Leno; Chambers, Holding, Gabriel, Cedric; Elneny, Xhaka; Pepe, Ceballos, Saka; Aubameyang
Watch the Sports Mole Football Shorts prediction for this game below: