Spurs, who currently sit 10th in the Premier League table, have won just one of their last 28 top-flight away encounters against the Gunners and lost 2-1 in this fixture last season.
Nuno has been boosted by the return of Lucas Moura, who is named in today's starting lineup, however Steven Bergwijn remains out with an ankle injury, while Ryan Sessegnon is nursing a hamstring problem.
✊ Your North London Derby XI. pic.twitter.com/MsUrstgozT— Tottenham Hotspur (@SpursOfficial) September 26, 2021
Dele Alli and Tanguy Ndombele retain their midfield roles, while Pierre-Emile Hojbjerg starts ahead of Oliver Skipp, who takes his place on the substitutes bench alongside fellow midfielders Giovani Lo Celso and Bryan Gil.