The Gunners' game with Chelsea later today will be the Dutchman's 50th appearance of the season and Wenger believes that he has managed to stay largely injury-free because he looks after his body in much the same way as the New York Red Bulls star.
"He has a very healthy life, very focused on football. He takes care of everything," said Wenger. "That's why he manages to do that. He is like Thierry Henry in that respect.
"Let's not put too much pressure on him. We cannot ask for too much more from Robin, he has given absolutely everything and he will again against Chelsea.
"If we create the chances, he will score."
Van Persie has scored 38 goals so far this campaign and is the clear favourite to win the PFA Player of the Year award on Sunday evening.