Westbrook's 29 points, 14 assists and 10 rebounds lifted the Thunder to a third successive win after a fixture in which they led for almost the entirety of the match.
Damian Lillard and C.J. McCollum had 34 points and 31 points respectively for the Trail Blazers, whose three-match winning streak was snapped.
Dennis Smith Jr's 17 points and eight rebounds helped the Dallas Mavericks come back from an early deficit in the fourth quarter to clinch a 106-98 victory over the Los Angeles Clippers.
The Clippers led 88-83 heading into the final quarter but some wayward shooting allowed the Mavericks to steal in and get the win.
Karl-Anthony Towns led the way with 25 points, 18 rebounds and seven assists in the Minnesota Timberwolves' 118-91 triumph over the Phoenix Suns.
Kyle Lowry and Fred VanVleet each scored 19 points as the Toronto Raptors saw off the Sacramento Kings 120-105.