The home side, who were greeted with a standing ovation, made a quick start to the match and found themselves with a 10-point lead by the end of the first quarter. DeAndre Jordan led the way for his side, going on to finish the game with a playoff career-high of 25 points.
The Clippers continued to dominate in the second quarter, extending their advantage to 15 by the break, with Chris Paul also among the points.
The visitors never looked like getting back into the game, as Klay Thompson was the only Warriors player to score more than 20 points.
The win gives the Clippers a 3-2 lead over the Warriors in their first-round playoff series, with the sixth game taking place tomorrow.