In all, Paul Lambert makes five changes from the side that lost 3-1 at Derby County last weekend as he looks to end the season on a positive note.
Nouha Dicko leads the line in an expected 4-2-3-1 formation, with attacking support from Andi Weimann - potentially making his final Wolves appearance before returning to the Rams - and youngsters Jordan Graham and Bright Enobakhare, who come in for Marshall, Lee Evans and the suspended Ivan Cavaleiro.
For Graham, the game marks his first start in 15 months after a lengthy layoff with a knee injury.
Dave Edwards and Romain Saiss are expected to operated in a holding role in front of the back four, which sees the returns of Silvio and skipper Danny Batth alongside Conor Coady and Kortney Hause, in for George Saville and Mike Williamson.
For visiting Preston, Simon Grayson makes three alterations from the side that were held to a 1-1 home draw by relegated Rotherham United last weekend.
Stevie May, who grabbed the equaliser against the Millers, continues his partnership up front with Jordan Hugill, while midfield duo Ben Pearson and Paul Gallagher return from suspension, replacing Daniel Johnson and Alan Browne alongside Tom Barkhuizen on the right wing and Aiden McGeady on the left.
Wolverhampton Wanderers: Burgoyne; Coady, Batth, Hause, Silvio; Edwards, Saiss; Graham, Enobakhare, Weimann; Dicko
Subs: Lonergan, Stearman, Saville, Mason, Evans, Iorfa, Bodvarsson
Preston North End: Maxwell; Browning, Baptiste, Boyle, Spurr; Barkhuizen, Gallagher, Pearson, McGeady; Hugill, May
Subs: Hudson, Huntington, Johnson, Browne, Horgan, Robinson, Beckford
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