Of those to make way from the win over Chelsea here, David de Gea, Marouane Fellaini, Ander Herrera and Ashley Young all drop down to the bench, but Matteo Darmian misses out on selection in the 18-man squad.
In terms of the visitors, who have lost on three of their previous four visits to Old Trafford, they are boosted by the return of fit-again top scorer Lukasz Teodorczyk from the first leg.
Teodorczyk has netted five times in the Europa League this season - the same number as Ibrahimovic - and is back involved after a 72-minute runout in Anderlecht's win at Oostende last time out.
Manchester United: Romero; Valencia, Bailly, Rojo, Shaw; Carrick, Pogba; Rashford, Mkhitaryan, Lingard; Ibrahimovic
Subs: De Gea, Rooney, Martial, Blind, Young, Herrera, Fellaini
Anderlecht: Ruben; Appiah, Mbodji, Spajic, Obradovic; Tielemans, Dendoncker, Hanni; Chipciu, Teodorczyk, Acheampong
Subs: Boeckx, Deschacht, Bruno, Capel, Nuytinck, Thelin, Stanciu
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