Man United had a whole host of chances to win the tie in the second period, but wasteful finishing from the 20-time English champions saw the quarter-final head for extra-time following an aggregate score of 2-2.
Marcus Rashford scored the vital goal in the 107th minute, however, to send Man United into the semi-finals with a 2-1 victory on the night.
Read how it all unfolded in Sports Mole's minute-by-minute live commentary of the action below.
MAN UNITED: Romero; Valencia, Bailly, Rojo, Shaw; Carrick, Pogba; Rashford, Mkhitaryan, Lingard; Ibrahimovic
ANDERLECHT: Ruben; Appiah, Mbodji, Spajic, Obradovic; Chipciu, Tielemans, Dendoncker, Hanni, Acheampong; Teodorczyk
8 - Jose Mourinho has won his last eight European home games as manager, including all five with Man Utd this season. Stronghold.— OptaJoe (@OptaJoe) April 20, 2017