The champions got back to winning ways last weekend against Bath following a run of three straight defeats.
Worcester have been in woeful form as of late, losing eight of their previous nine games.
Quins will field the same side that won the championship at Twickenham Stadium last season - the first time that they have done that during the current campaign.
Worcester: Pennell, Drauniniu, Grove, Clarke, Howard, Goode, Arr, Taulava, Kvesic, Best, Jones, Percival, Murray, Shervington, Mullan
Replacements: Lutui, O'Donnell, Andress, Gillies, Abbott, Perry, Gray, Carlisle
Quins: Brown, Williams, Lowe, Turner-Hall, Monye, Evans, Care, Easter, Robshaw, Fa'asavalu, Robson, Kohn, Johnston, Gray, Marler
Replacements: Buchanan, Lambert, Collier, Matthews, Guest, Dickson, Botica, Chisholm
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