Both forwards are established England internationals; Mako, 25, has racked up 29 caps, while his 23-year-old brother Billy has 23 appearances to his name.
Mako joined Saracens from Bristol in 2011 and his sibling followed in the loosehead prop's footsteps two years last from Wasps.
Mako told the club's official website: "Signing a new contract comes with new responsibility and I am really looking forward to contributing to Saracens in the upcoming years. We're extremely happy to extend our stay at the club, as we have made so many fantastic memories together already.
"One of the most important things is that we're playing alongside our best mates, week-in-week-out, and the whole culture of the club means it's a special place to play rugby. I'm delighted to be staying."
Billy added: "We are both delighted to be able to extend our deals. Now is time to build on the work we have already done with Saracens and continue to improve as people and players. We have a lot to look forward to over the rest of the season and beyond. We're very excited to stay at Saracens."
Saracens director of rugby Mark McCall said: "This is fantastic news for everyone associated with the club. To have two players of the calibre of Mako and Billy commit their futures to Saracens is extremely exciting, as we continue to build a strong squad for the upcoming seasons.
"We have a great blend of youth and experience at the club and what has been great is for us to witness the progression of both of them from promising youngsters to two of the world's best in their respective positions. They also contribution off the field is equally as important and we're delighted to keep them at the club."
Both players won their first Aviva Premiership title with Saracens in 2015.