The 30-year-old, who joined Sarries from Sale Sharks in 2010, will reach the milestone tomorrow in the Aviva Premiership clash against Worcester Warriors.
"I'm pretty happy to get to 100 appearances, to be honest," Wigglesworth told the club's official website. "It wasn't that long ago where I think it was only [Neil de Kock], after the so-called "clear out", that was on 100 games at the club.
"The latest inductees seem to be coming thick and fast these days, and I think that shows just how far we've come a core group. The lads are already joking that the standard of these 100 club dinners and lunches will be slipping rapidly."
A win for Saracens this weekend will guarantee them top spot in the Aviva Premiership table.