Since arriving at Allianz Park in 2009, the 32-year-old has gone on to make 113 appearances for the Aviva Premiership side.
"Sunday will be the end of something really special for me," the back-rower told the club's official website.
"Going into the game knowing that it's the last time I'll ever run out on a rugby field is actually quite a nice feeling, as in this game you don't get to do that very often.
"I just want to make it an incredible experience, and I hope it's just a great occasion and that the boys do well on the day as well."
Director of rugby Mark McCall added: "Jacques has been an amazing player and person for Saracens. He set a phenomenal example on the field with his bravery and the way that he gave everything he could in every game that he played.
"Off the field, his resilience and resolve to deal with a potentially career ending injury was both remarkable and inspirational. He will always be remembered as one of the true greats of Saracens and hopefully we can give him the send-off he so richly deserves on Sunday."
Burger further revealed that once his boots have been hung up, he will return to his native Namibia to begin a career as a farmer.