The Sharks would move 12 points ahead of bottom side London Welsh with a win, which would leave the Welsh requiring three big wins from their remaining fixtures.
Gloucester, on the other hand, would move up to third with the four points.
Sale:Shepherd, Addison, Leota, Tuitupou, Cueto, Macleod, Peel, Gaskell, Seymour, Braid, Ostrikov, Myall, Thomas, Jones, Dickinson.
Replacements: Taylor, Harrison, Buckley, Holmes, Powell, Fowles, Cipriani, Brady
Gloucester: Cook, May, Tindall, Twelvetrees, Monahan, Burns, Robson, Kalamafoni, Qera, Savage, James, Lokotui, Chistolini, Edmonds, Wood.
Replacements: Britton, Murphy, Thomas, Morgan, Hazell, Lewis, Trinder, Sharples
Sports Mole says: Gloucester just too strong, winning a close one.