The Saints are currently top of the Aviva Premiership table with five wins from their first six matches, while Sarries sit two points worse off in fourth place.
The hosts are unbeaten in their last five games at home in all competitions, but their opponents have triumphed on the road on the last three occasions.
Northampton have made three changes for the clash as Paul Doran Jones, Mark Sorenson and GJ Van Velze all come into the side.
Meanwhile, David Strettle, Joel Tomkins and Alistair Hargreaves all start for Saracens.
Northampton: Myler, K Pisi, G Pisi, Waldouck, Artemyev, Lamb, Dickson, Van Velze, Wood, Dowson, Sorenson, Lawes, Doran Jones, Hartley, Tonga'uiha
Replacements: Haywood, Waller, Mujati, Manoa, Oakley, Roberts, May, Burrell
Saracens: Goode, Ashton, Tomkins, Barritt, Strettle, Farrell, De Kock, Wray, Fraser, Brown, Hargreaves, Borthwick, Stevens, Brits, Vunipola
Replacements: Smit, Auterac, Nieto, Botha, Joubert, Wigglesworth, Hodgson, Wyles
Sports Mole says: Northampton to edge a close encounter