The West Country club, who are in sixth place in the table, come into the match with one win in their last three league games.
Fifth-placed Northampton have fared even worse in recent weeks, losing three out of four matches.
Northampton: Wilson, K Pisi, G Pisi, Waldouck, Elliott, Myler, Dickson, Tonga'uiha, Haywood, Mercey, Manoa, Sorenson, Dowson, Nutley, Van Velze
Replacements: McMillan, Waller, Doran Jones, Craig, Oakley, Roberts, Lamb, May
Gloucester: Cook, Sharples, Tindall, Molenaar, May, Mills, Robson, Wood, Dawidiuk, Harden, Lokotui, James, Savage, Qera, Kalamafoni
Replacements: d'Apice, Murphy, Thomas, Buxton, Cox, Cowan, Monahan, Thomas
Sports Mole says: Northampton to snatch the spoils