Owen Farrell, Brad Barritt, Chris Ashton, Mouritz Botha, Alex Goode and Mako Vunipola are all unavailable due to England call-ups, but hooker Schalk Brits will wait until after the match before joining up with South Africa.
Wasps, meanwhile, have made five changes to their side as they look to continue their recent good form.
Saracens: Wyles, Strettle, Tomkins, Ratuvou, Short, Hodgson, Wigglesworth; Stevens, Brits, Nieto, Borthwick, Hargreaves, Brown, Saull, Joubert
Replacements: Smit, Auterac, du Plessis, Kruis, Fraser, de Kock, Mordt, Maddock
Wasps: Southwell, Varndell, Daly, Bell, Wade, Robinson, Davies; Payne, Thomas, Taulafo, Launchbury, Wentzel, Johnson, Haskell, Vunipola
Replacements: Lindsay, Swainston, McIntyre, Cannon, Poff, Holmes, Bell, Masi