Dai Young's side have been in dominant domestic form in recent weeks and currently sit level on points with fourth-placed Gloucester Rugby.
Meanwhile, struggling Irish can pull further away from the relegation zone with a victory at the Madejski Stadium following Sale Sharks' defeat to Harlequins on Friday night.
London Irish: WWWLWL
London Irish: Homer, Ojo, Armitage, Geraghty, Yarde, Humphreys, Phibbs, Hala'ufia, Treviranus, Garvey, Evans, Skivington, Aulika, Lawson, Lahiff
Replacements: McGregor, Yanuyanutawa, Halavatau, Low, Gibson, Fisher, Tagicakibau, Moates
Wasps: Southwell, Wade, Daly, Bell, Varndell, Jones, Simpson, Jones, Poff, Johnson, Wentzel, Cannon, Taylor, Rhys Thomas, Taulafo
Replacements: Lindsay, McIntyre, Romano, Rae, Everard, Davies, Robinson, Hayter
Sports Mole says: Wasps to run out winners