Spurs looked to have ended any talk of a Wembley hoodoo with their 3-1 Champions League win over Borussia Dortmund on Wednesday, but their poor domestic form at the temporary home continued with a goalless draw against Swansea City this afternoon.
Tottenham have already dropped seven points from three games in front of their own fans this season - more than they did in the entire 2016-17 campaign at White Hart Lane - but Pochettino played down the significance of their dip in home form.
"The reality is that we dropped a lot of points after three games but I am not worried. We could spend one season talking about that and maybe at the end then you can see it or everyone can say, 'Yes, Wembley was a problem'," he told reporters.
"It's true that last season was a fantastic season at White Hart Lane. But today we are at Wembley and White Hart Lane is in the history.
"We are building a new stadium which will be fantastic and then I believe that every single season is completely different. We cannot compare last season with this season."
Tottenham's next league game at Wembley is three weeks away, with Bournemouth the visitors on October 10.