The Bundesliga side, who can qualify for the last 32 of the competition with a win this evening, have made one alteration in defence with Junior Caicara coming in.
Schalke 04: Fahrmann; Caicara, Matip, Neustadter, Aogo; Sane, Goretzka, Geis, Choupo-Moting; Huntelaar, Di Santo
Subs: Gspurning, Kolasinac, Kaan Ayhan, Riether, Meyer, Hojbjerg, Reese
APOEL: Waterman; Sergio, Carlao, Guilherme, Antoniades; Morais; Vinicius, De Vincenti, Charalambides, Morais; Sotiriou
Subs: Kissas, Inaki Astiz, Alexandrou, Makridis, Stilic, Piątkowski, Vander