Pep Guardiola's side will be hoping to wrestle the title back from Liverpool this season, but face a difficult opening test against a team that beat them home and away last term.
Six teams finished above Wolves in the final Premier League table last season, but for Manchester City this could be just about the toughest opening game they could have faced.
Wolves did the league double over the then-champions in 2019-20, and on Monday night could become the first team to ever beat a Guardiola side in three successive league matches.
All of the stats suggest that Wolves are Man City's bogey team beyond just last season too; excluding penalty shootouts, Guardiola only has a losing record against two managers he has faced at least five times - Nuno Espirito Santo and Jurgen Klopp.
The 3-2 triumph in the corresponding fixture at Molineux last season also saw Wolves record 62.2% possession - the highest percentage any club has managed against a Guardiola team in any competition.
That statistic should be qualified with the fact that Man City were reduced to 10 men early on in that match, but that will not change Guardiola's expectancy of how difficult this contest will be.
Such is the standard at the top of the Premier League now that any dropped points - even in the opening fixture - could prove costly, and if Liverpool overcome Chelsea on Sunday then Man City will once again find themselves playing catch-up from an early stage.
On the plus side, their opening-day record is superb; City are unbeaten in their last 11 Premier League curtain-raisers, and victory at Molineux would see them win a record 10th in a row.
City ended last season strongly too with five successive league victories, scoring 21 goals and conceding just once in the process.
However, they were beaten seven times away from home in the league last term and, while they were also some way adrift of Liverpool in terms of home form, it is that record on their travels which will need the most improvement if they are to close the gap on the champions.
For their part, Wolves will have their sights set on European qualification once again after finishing seventh for a second season in a row last term.
The new campaign could not have begun any better with Wolves making the quickest start to a season in Premier League history, racing into a 2-0 lead within six minutes at Sheffield United on Monday.
That was how it finished as Nuno's side made an early statement against one of their fellow European hopefuls from last season, with Raul Jimenez in particular looking sharp.
However, there was disappointment in midweek as a 1-0 defeat at home to Stoke City sent them out of the EFL Cup despite naming a number of regular first-teamers in their starting XI.
Those players can expect a much tougher test against a Man City side champing at the bit to get going again, but their recent record in this fixture will fill them with confidence of picking up another positive result.
Wolverhampton Wanderers Premier League form: W
Wolverhampton Wanderers form (all competitions): WL
Manchester City form (all competitions): N/A
Guardiola has confirmed that club-record goalscorer Sergio Aguero could be sidelined for a further two months with the knee injury he has carried over from last season.
Bernardo is suffering from a quadriceps strain he picked up on international duty, while Mahrez is still working his way back up to fitness following a positive coronavirus test.
Mahrez is thought to be closer to full fitness than Aymeric Laporte, who also returned a positive COVID-19 test and could miss out on Monday night as a result.
City also confirmed on the morning of the match that Ilkay Gundogan has now tested positive for coronavirus too, ruling him out of the game.
Wolves will be without long-term absentee Jonny, but Nuno otherwise has a clean bill of health as he prepares to welcome the former champions.
Summer signing Fernando Marcal is likely to fill in for him at left wing-back again, while Traore could revert to right wing-back for this match, despite having scored three of his four league goals last season against Man City.
Diogo Jota will not play any part as he closes in on a move to Liverpool.
Wolverhampton Wanderers possible starting lineup:
Patricio; Boly, Coady, Saiss; Traore, Neves, Moutinho, Marcal; Podence, Jimenez, Neto
Manchester City possible starting lineup:
Ederson; Walker, Garcia, Ake, Mendy; De Bruyne, Rodri, Foden; Mahrez, Jesus, Sterling
We say: Wolverhampton Wanderers 2-2 Manchester City
This is a bogey fixture for Man City and would certainly not have been Guardiola's first choice for their opening game.
Both teams have attacking units which can cause plenty of problems for the opposition, and we are backing an entertaining draw at Molineux.
Top betting tipOur expert tipster partners at Sporita.com are predicting under 3.5 goals in this match. Click here to find out what else they are predicting for this game and for more of their tried-and-tested football tips.Under 3.5:data
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