That result came days after Guardiola's men had advanced to the EFL Cup final with a dominant win at the home of their bitter rivals Manchester United, and City have certainly hit top gear at a crucial time of the campaign.
Wednesday's hosts are unbeaten in 13 and are on a six-game winning streak in all competitions - scoring 15 and conceding just twice in that run - and have propelled themselves into title contention as the season approaches its midway point.
As things stand, Guardiola's men occupy fifth spot in the table, but reigning champions Liverpool - who have begun to falter recently - are only four points clear of City having played two games more.
Despite their well-documented defensive injuries, Guardiola's rearguard continue to perform valiantly on a consistent basis and have shipped just three goals in their last 10 home matches in all competitions, largely thanks to the resurgent John Stones and reliable Ruben Dias.
While City claimed a dominant win to advance in the FA Cup, Brighton only just managed to avoid sharing Leeds United's fate after scraping past Newport on penalties at Rodney Parade.
Seagulls goalkeeper Jason Steele did not cover himself in glory over the full 120 minutes, but the 30-year-old quickly went from villain to hero as he saved four penalties in a dramatic finale, with Brighton edging the shootout 5-4 to avoid being on the wrong end of another giant killing.
Manager Graham Potter described the experience as "traumatic" as the Seagulls managed to end their eight-game winless run, and the 45-year-old will be desperate to see his side carry that momentum forward in the Premier League, where Brighton can only boast a solitary win from their last 15 attempts.
While the three sides below them in Fulham, West Bromwich Albion and Sheffield United have also endured barren runs without victory, Brighton's dismal form means that only three points separate them from the drop zone after 17 matches, and Fulham do have two games in hand over the relegation-threatened Seagulls.
Man City boast a 100% record against Brighton since the South Coast side earned promotion to the Premier League, and this week's visitors have never won a league game on the Citizens' turf.
Manchester City Premier League form: WDDWWW
Manchester City form (all competitions): WWWWWW
Brighton & Hove Albion Premier League form: LDDDLD
Brighton & Hove Albion form (all competitions): DDDLDW
City's star man Sergio Aguero has scored every time he has faced Brighton in the Premier League, but the Argentine will miss out here after coming into contact with a COVID-positive individual.
However, Aymeric Laporte and Nathan Ake both remain sidelined through injury, and there is a question mark over Raheem Sterling's involvement after he missed out the FA Cup win due to a lack of match fitness, but he should make the first XI here.
Steele's shootout heroics will probably not be enough to see him keep his place in goal over Robert Sanchez, while Leandro Trossard will be aiming to put his penalty miss behind him as he earns a recall to the attack.
Manchester City possible starting lineup:
Ederson; Cancelo, Stones, Dias, Mendy; Rodri, Gundogan; Silva, De Bruyne, Sterling; Jesus
Brighton & Hove Albion possible starting lineup:
Sanchez; Webster, Dunk, Burn; Veltman, Propper, White, March; Trossard, Mac Allister; Maupay
We say: Manchester City 3-0 Brighton & Hove Albion
Manchester City have not been their usual dominant selves on the attacking front throughout the campaign, but at the other end of the pitch, their defensive prowess is evident. Brighton supporters will not be looking ahead to this tie with any optimism whatsoever, and this should be a routine win for Guardiola's men over the struggling Seagulls.
Top betting tip
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