Klopp, however, feels that Man City have more than enough options to make up for De Bruyne's absence, and even admitted to wanting to sign him several years ago while managing Borussia Dortmund.
When asked by Sky Sports News if the injury evens the playing field in the Premier League, Klopp replied: "I think somebody who thinks like that, about a situation like that, is an asshole, to be honest. I am not like that. First of all, I wish him the absolute very best.
"I love this player, I wanted him desperately when I was at Dortmund and he was at Chelsea, but Jose didn't give him to me! What a season he had, what a World Cup he played. I really feel for him.
"They have options of course, like they always have options, they brought in Riyad Mahrez, but they can all play in different positions. Bernardo Silva can play a bit deeper, Foden can play in positions, Gundogan can play in positions.
"Nobody needs to worry about Man City and their quality, there is still a lot there. We don't look at the other teams, we really only try to make the best of our situation, and that will hopefully work."
De Bruyne only made an appearance from the bench as City beat Arsenal at the Emirates Stadium last weekend.