Liverpool need to beat Napoli by three or more goals on Tuesday in order to overtake them into top spot in Group A of the Champions League.
The visitors, meanwhile, head to Anfield having put together a remarkable 13-match winning streak in all competitions, and they will be aiming to maintain their 100% record in this season's competition.
Here, Sports Mole rounds up Liverpool's latest injury and suspension news ahead of their clash with Napoli.
Luis Diaz
Status: Out Type of injury: Knee Possible return date: December 26 (vs. Aston Villa)
Luis Diaz suffered a serious knee injury against Arsenal earlier this month, and the Colombia winger will not feature for the club again until after the end of the upcoming World Cup.
Joel Matip
Status: Out Type of injury: Calf Possible return date: November 6 (vs. Tottenham Hotspur)
Joel Matip sustained a calf injury during the 3-2 defeat at the Emirates Stadium, with the central defender fighting a race against time to be available again before the World Cup.
Naby Keita
Status: Out Type of injury: Thigh Possible return date: November 6 (vs. Tottenham Hotspur)
Naby Keita has resumed training following a serious calf injury which has kept him out for the majority of the campaign, but he was not included in Liverpool's Champions League squad and therefore may be targeting a return away to Tottenham on Sunday.
Arthur
Status: Out Type of injury: Thigh Possible return date: Unknown
Arthur underwent surgery on a serious thigh injury earlier this month and it remains unclear when the midfielder, who is on loan for the season from Juventus, will be available again.
Diogo Jota
Status: Out Type of injury: Calf Possible return date: December 26 (vs. Aston Villa)
Diogo Jota suffered a serious calf injury in the dying stages of his side's 1-0 win against Manchester City earlier this month, with the Portugal forward ruled out of the World Cup as a result.
LIVERPOOL'S SUSPENSION LIST
Liverpool have no players suspended for the clash with Napoli.