Danny Swanson makes his debut for the club after joining on Wednesday following his release by Coventry City.
Sean McKirdy is handed his first start and Sam Nicholson is also brought in to replace Morgaro Gomis, who is absent due to a family bereavement, while Jamie Walker and Billy King both drop to the substitutes' bench.
Callum Paterson continues at left-back for the visitors after his red card in the defeat to Hamilton Academical was rescinded.
Inverness Caledonian Thistle: Fon Williams; Raven, Tremarco, Vincent, Meekings; Draper, Devine, Tansey, Williams; Christie, Storey
Subs: Esson, Lopez, Forran, Wedderburn, Horner, Sho-Silva, Vigurs
Hearts: Alexander; Paterson, Ozturk, Rossi, Oshinawa; Buaben, McKirdy, Swanson, Nicholson; Sow, Juanma
Subs: Hamilton, Augustyn, McGhee, Pallardo, King, Walker, Reilly