Kai Havertz and Timo Werner were both last-minute absentees from the FA Cup final defeat to Liverpool, joining Ben Chilwell and Callum Hudson-Odoi on the sidelines, but the former has a slight chance of being involved.
Andreas Christensen also reportedly refused to play at Wembley and disappeared from the team hotel, leading to speculation that he could have played his final game for the club ahead of a summer departure.
Tuchel will need to assess the fitness of the rest of his crop after more than 120 minutes of FA Cup action, with Thiago Silva in particular likely to be rested as Cesar Azpilicueta returns to the fold.
Mason Mount is unlikely to be considered for the drop despite his fatal penalty miss in the shootout against Liverpool, while Romelu Lukaku aims to score in three consecutive Premier League games for the first time since September 2017.
Chelsea possible starting lineup: Mendy; Azpilicueta, Chalobah, Rudiger; James, Kante, Jorginho, Alonso; Ziyech, Mount; Lukaku