The Premier League club have been eager to build a new ground, but a number of the club's supporters have not been open to the switch.
"The most important thing for us is to position ourselves regarding our future," said Villas-Boas. "The club has made a wise decision in that sense.
"I'm not in a position to say how the fans will react, and how they are reacting. In the beginning, disappointment regarding the loss - or not - of an historic site can mean something.
"But eventually, if we move or not, things will be for the best for sure."
Chelsea resume their Premier League campaign with a home fixture against Everton this weekend.