Benitez said that his players will need to adapt to the synthetic pitch at the Tsentralnyi Stadion, but is confident of progressing.
"We have a lot of respect for Rubin Kazan," the club's official website quotes the Spaniard as saying. "We know they are a good team. For us to lose [players] is not ideal, we have to manage the situation and we have confidence we can go through.
"In terms of the game, I think we know their team so they can do well, so maybe we have to react but I have confidence we can do well anyway. I don't see too many surprises.
"You have to play on a synthetic pitch and adapt to that but it will be the same for everyone."
Benitez won the competition with Valencia in 2004.